Not Yet RecruitingNot Applicable

Effect of Hand Rehabilitation on Cognitive Function in Patients With PD

48 participantsStarted 2026-08-23

Plain-language summary

Evidence suggests the association between fine motor skills of the hand and cognitive function, as well as the positive effects of hand rehabilitation on hand function and the effectiveness of cognitive rehabilitation on cognitive functions in patients with Parkinson's disease (PD). In response to the question of whether there is a cause-and-effect relationship between fine manual skills and cognitive function, we designed the present randomized controlled trial to investigate the effectiveness of sensory-motor rehabilitation of the hand on cognitive functions compared to the effectiveness of cognitive rehabilitation on sensory-motor skills of the hand in patients with PD. In this double-blinded, randomized controlled trial, a convenience sample including 48 people with PD will participate based on simple non-random sampling. The participants will be allocated randomly through stratified randomization to parallel groups of intervention (sensorimotor hand rehabilitation) and control (cognitive rehabilitation) with a 1:1 allocation ratio. The associate researcher responsible for assessing outcome measures and the statistician responsible for analyzing the data are blinded to the intervention protocol. The intervention protocol for the intervention group includes hand sensory-motor rehabilitation for 10 one-and-a-half-hour sessions, 3 sessions per week, in addition to cognitive rehabilitation for 10 one-and-a-half-hour sessions, 3 sessions per week. The intervention protocol for the control group includes cognitive rehabilitation for 10 one-and-a-half-hour sessions, 3 sessions per week. All participants undergo three assessment sessions: the day before the intervention, the day after the intervention, and one month after the last intervention session. Data will be analyzed using SPSS version 22.0. The significance level will be set at 0.05.

Who can participate

Age range

45 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. A diagnosis of PD by a neurologist based on the Movement Disorders Society Clinical Diagnostic Criteria for Parkinson's Disease;
. 45-65 years old: age of peak incidence of PD;
. Minimum 2 years and maximum 10 years from initial diagnosis: stabilization of the disease process and medications;
. disability level of at most 3 in the Modified Hoehn and Yahr Scale: physically independent;
. Mild cognitive impairment: score between 20 and 26 in Montreal cognitive assessment;
. Signing the written informed consent.

Exclusion criteria

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1This trial is looking at whether hand rehabilitation might improve cognitive function in Parkinson's disease — is there enough existing evidence behind this idea that it would be worth discussing as a potential option for my situation?
2The trial isn't recruiting yet, so there's no safety or outcome data available from it — given that, would you recommend I consider other ongoing or established treatments in the meantime rather than waiting to see if I qualify?
3The study is measuring a wide range of outcomes including memory and reaction time tests, pain, grip strength, and hand sensation — does that level of testing sound manageable given my current symptoms and stamina?
4Since this trial has no assigned phase, it may be more exploratory in nature — what does that mean in practical terms for what we'd learn about whether hand rehab actually helps cognition in Parkinson's?
5Are there already standard hand therapy or cognitive rehabilitation programs available to me that address some of these same goals, so we can compare what a trial like this might add versus what I could access right now?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Montreal Cognitive Assessment

Timeframe: - The day before the intervention - The day after the intervention - One month after the last intervention session

Cambridge Neuropsychological Test Automated Battery - Reaction Time

Timeframe: - The day before the intervention - The day after the intervention - One month after the last intervention session

Cambridge Neuropsychological Test Automated Battery - Spatial Span Test

Timeframe: - The day before the intervention - The day after the intervention - One month after ending intervention

Cambridge Neuropsychological Test Automated Battery - Match to Sample Visual Search Test

Timeframe: - The day before the intervention - The day after the intervention - One month after the last intervention session

Cambridge Neuropsychological Test Automated Battery - Stop Signal Task

Timeframe: - The day before the intervention - The day after the intervention - One month after the last intervention session

KING'S PD Pain Scale

Timeframe: - The day before staring intervention - The day after ending intervention - one month after ending intervention

Trial details

NCT IDNCT07702929

SponsorIsfahan University of Medical Sciences

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-07-23

Contact for this trial

Hamid Reza Rostami, PhD

00989134328034 hrr.rostami@gmail.com

View on ClinicalTrials.gov More PARKINSON DISEASE (Disorder) trials

Plain-language summary

Who can participate

Age range

45 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. A diagnosis of PD by a neurologist based on the Movement Disorders Society Clinical Diagnostic Criteria for Parkinson's Disease;
. 45-65 years old: age of peak incidence of PD;
. Minimum 2 years and maximum 10 years from initial diagnosis: stabilization of the disease process and medications;
. disability level of at most 3 in the Modified Hoehn and Yahr Scale: physically independent;
. Mild cognitive impairment: score between 20 and 26 in Montreal cognitive assessment;
. Signing the written informed consent.