Corheart 6 LVAS Clinical Investigation

Inclusion Criteria: * Age ≥ 18 years and ≤ 75 years * The patient has signed an Informed Consent Form * Body Surface Area (BSA) ≥ 1.2 m2 * New York Heart Association (NYHA) Class IV * Left Ventricular Ejection Fraction (LVEF) ≤ 25% * Despite the optimal medical management based on current guidelines, the patient must also meet one or more of the following: * \- - a. Unable to exercise for HF, or if able to perform cardiopulmonary testing, with peak VO2 \<12 mL/kg/min and/or \< 50% predicted value; * \- - b. Progressive end-organ dysfunction (worsening renal and/or hepatic function, type II pulmonary hypertension, cardiac cachexia) due to reduced perfusion and not to inadequately low ventricular filling pressure (PCWP \> 20 mmHg and SBP \< 90 mmHg or CI \< 2.0 L/min/m2). * \- - c. Impella or IABP assisted; Inotrope dependent/unable to wean from inotropes. Exclusion Criteria: * Heart failure who can be treated with other therapy options (e.g. CRT, CRT-D, etc.) * Intolerance to anticoagulant or antiplatelet therapies or any other peri/post-operative therapy the investigator will require based upon the patients' health status. * Patient has known hypo or hyper coagulable states such as disseminated intravascular coagulation and heparin induced thrombocytopenia type II. * Platelet count \< 100,000 x 103/L (\< 100,000/ml). * Psychiatric disease/ disorder, irreversible cognitive dysfunction or psychosocial issues that are likely to impair compliance with the study protocol and le…