A Study to Evaluate Efficacy, Safety and Tolerability of Remibrutinib in Adult Participants With Severe Chronic Pruritus of Unknown Origin (CPUO)

Key Inclusion Criteria: * Participant must be ≥ 18 years of age, at the time of signing the informed consent. * Participants with chronic pruritus for at least 4 months prior to screening. * Chronic pruritus considered of unknown origin as assessed by the investigator at baseline (e.g., excluding chronic pruritus related to primary dermatological or systemic conditions, neuropathic or psychogenic origin or secondary to drugs or other allergen exposures). * Chronic pruritus must affect at least 2 of the following body areas: trunk, arms, or legs (cannot be unilateral and/or dermatomal in distribution). * Participants with ongoing, severe chronic pruritus despite the use of emollients and who are candidates for systemic therapy. * Participants must have severe itch defined by a WI-NRS ≥7 at screening; score scale ranges from 0 to 10; higher score indicates worse itch. * Participants must have an average WI-NRS ≥7 over the 7 days prior to randomization/baseline visit. * The average WI-NRS score over the preceding 7 days prior to the randomization/baseline visit will be calculated based on the daily WI-NRS scores (0-10). * Participants must have PGIS of pruritus scored as 3 "severe" at screening and baseline visits. Key Exclusion Criteria: * Any active skin conditions (e.g., atopic dermatitis, psoriasis, etc.) that may interfere with the assessment of CPUO. * Known systemic condition(s) or medication(s) that are considered by the investigator to be the primary cause of current…