Efficacy of PosBion® Postbiotic Supplementation in Adults With Irritable Bowel Syndrome (NCT07699926) | Clinical Trial Compass
CompletedNot Applicable
Efficacy of PosBion® Postbiotic Supplementation in Adults With Irritable Bowel Syndrome
Malaysia55 participantsStarted 2026-01-01
Plain-language summary
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by recurrent abdominal pain and altered bowel habits, often associated with impaired intestinal barrier function, low-grade inflammation, and dysregulation of the gut-brain axis. Postbiotics have emerged as a promising therapeutic approach due to their immunomodulatory, anti-inflammatory, and gut barrier-protective properties.
This completed single-arm, open-label clinical study evaluated the efficacy of PosBion® postbiotic supplementation in adults with IBS over a 12-week intervention period. The study assessed changes in IBS symptom severity, quality of life, gastrointestinal health, inflammatory biomarkers, intestinal barrier integrity, mucosal immunity, oxidative stress, and gut-brain axis biomarkers using validated questionnaires and salivary biomarker analyses.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Experienced one or more symptoms consistent with irritable bowel syndrome (IBS), including:
* Stomach pain or abdominal cramps
* Bloating
* Excessive gas
* Diarrhoea
* Constipation (or alternating diarrhoea and constipation)
* Mucus in stool
* Urgency to defecate
* Sensation of incomplete bowel evacuation
* Willing and able to comply with all study procedures and scheduled visits.
* Provided written informed consent before study participation.
Exclusion Criteria:
* History of chronic or serious medical conditions, including but not limited to diabetes mellitus, cardiovascular disease, chronic kidney disease, cancer, or chronic respiratory disease.
* Current use of supplements intended to improve gut health.
* Current use of antibiotics or antiviral medications.
* Current use of probiotic, prebiotic, or postbiotic supplements.
* Major surgery within the previous 6 months.
* Pregnant or breastfeeding women.
* Known allergy or hypersensitivity to any ingredient of the investigational product.
* Any condition that, in the opinion of the investigators, could interfere with study participation, compliance, or interpretation of the study results.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Irritable Bowel Syndrome Quality of Life (IBS-QOL) Score
Timeframe: Baseline, Week 4, Week 8, and Week 12
2
Change in Irritable Bowel Syndrome Symptom Severity Scale (IBS-SSS) Score