The Cohort Network for Adolescents and Youth With multipLe Mental Health Conditions (CALM) Master Observational Trial is a prospective, longitudinal observational study that seeks to improve clinical care for youth with multiple mental health conditions (MMHC), also known as mental health multimorbidity in the literature. MMHC is conceptualized as the presence of two or more mental health diagnoses under the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). MMHC is common in youth seeking mental health services and is associated with less favorable outcomes and greater health services utilization. Mental health disorders also accumulate in youth over time. The Master Observational Trial (MOT) will investigate MMHC in critical developmental periods in youth and identify risk and protective factors that will provide a mechanistic understanding of how MMHC develops over time. A subset of participants will also enroll in a Deep Phenotyping Cohort, which includes enhanced clinical and cognitive assessments and multimodal neuroimaging to investigate neurobiological mechanisms underlying MMHC and identify potential biomarkers of illness complexity and progression. In the near future, we aim to add to the current protocol to embed both a clinical trials network for youth mental health in Ontario and Calgary within the CALM study and add digital phenotyping using wearable technology to generate digital and physiological markers of MMHC. The current protocol focuses on establishing the longitudinal MOT cohort and Deep Phenotype Cohort only as a first step towards these long term CALM goals.
Age range
11 Years – 24 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Diagnostic Assessment for the Health Spectrum
Timeframe: Baseline and 24 months
Adolescent Health History
Timeframe: Baseline, 12 months, 24 months
Assessment of Quality of Life
Timeframe: Baseline, 3 months, 6 months, 12 months, 18 months, 24 months
Brain-CODE Demographic Form
Timeframe: Baseline, 12 months, 24 months
Brain-CODE Medical History Form incorporating Developmental History Questionnaire (DHQ) Items
Timeframe: Baseline, 12 months, 24 months
Canadian Health Survey on Children and Youth (CHSCY) Childhood Experiences Scale
Timeframe: Baseline, 12 months, 24 months
Child and Youth Resilience Measure
Timeframe: Baseline, 12 months, 24 months, 36 months
The Columbia Suicide Severity Rating Scale
Timeframe: Baseline, 24 months
Self-Injurious Thoughts and Behaviours Interview
Timeframe: Baseline, 24 months
Canadian Health Survey on Children and Youth (CHSCY) Bullying Scale
Timeframe: Baseline, 12 months, 24 months
Difficulties in Emotion Regulation Scale Short Form
Timeframe: Baseline, 12 months, 24 months, 36 months
Eating Disorder Examination Questionnaire (EDE-QS) Short Form
Timeframe: Baseline, 3 months, 6 months, 12 months, 18 months, 24 months
General Anxiety Disorder-7
Timeframe: Baseline, 3 months, 6 months, 12 months, 18 months, 24 months, 30 months, 36 months, 42 months
General Behaviour Inventory-10 Mania
Timeframe: Baseline, 3 months, 6 months, 12 months, 18 months, 24 months, 30 months, 36 months, 42 months
General Life Satisfaction
Timeframe: Baseline, 18 months, 30 months
The Goal-Based Outcome (GBO) Tool
Timeframe: Baseline, 3 months, 6 months, 12 months, 18 months, 24 months
Internalized Stigma of Mental Illness
Timeframe: Baseline
International Sedentary Assessment Tool
Timeframe: Baseline, 3 months, 6 months, 12 months, 18 months, 24 months
McMaster Family Functioning Scale
Timeframe: Baseline, 12 months, 24 months, 36 months
Treatment Log
Timeframe: Baseline, 6 months, 18 months, 24 months, 30 months, 36 months, 42 months
Ohio State University Traumatic Brain Injury Identification Method
Timeframe: 3 months, 30 months
Ontario Child Health Study Emotional Behavioural Scales - Brief
Timeframe: Baseline, 6 months, 24 months
Patient Global Improvement Scale
Timeframe: Baseline, 3 months, 6 months, 12 months, 18 months, 24 months
Patient Health Questionnaire
Timeframe: Baseline, 3 months, 6 months, 12 months, 18 months, 24 months, 30 months, 36 months, 42 months
Pittsburgh Sleep Quality Index
Timeframe: Baseline
Phlebotomy (blood) collection
Timeframe: Baseline, 12 months, 24 months
Physical Exam (Height, Weight, Body Mass Index, Waist Circumference, Neck Circumference, and Blood Pressure)
Timeframe: Baseline, 12 months, 24 months, 36 months
PRIME- Revised
Timeframe: Baseline, 3 months, 6 months, 12 months, 18 months, 24 months, 30 months, 42 months
Revised Child Anxiety and Depression Scale
Timeframe: Baseline, 3 months, 6 months, 12 months, 18 months, 24 months, 30 months, 36 months, 42 months
Saliva collection
Timeframe: Baseline, 12 months, 24 months
The Short Warwick-Edinburgh Mental Well-being Scale
Timeframe: Baseline, 3 months, 6 months, 12 months, 18 months, 24 months
The Social Communication Questionnaire
Timeframe: Baseline
Social Responsiveness Scale (SRS) - Short Form
Timeframe: Baseline, 12 months, 24 months, 30 months, 42 months
Strengths and Weaknesses of Attention-Deficit/Hyperactivity (SWAN) Disorder Symptoms and Normal Behavior scale
Timeframe: Baseline, 6 months, 12 months, 18 months, 24 months
Suicidal Ideation Questionnaire-Junior
Timeframe: Baseline, 3 months, 12 months, 24 months, 30 months, 42 months
Toronto Obsessive-Compulsive Scale - Brief
Timeframe: Baseline, 6 months, 12 months, 18 months, 24 months
Unmet Needs Questionnaire
Timeframe: 12 months, 24 months, 36 months
Youth Life Interference Scale
Timeframe: Baseline, 3 months, 6 months, 12 months, 18 months, 24 months
Kiddie Schedule for Affective Disorders and Schizophrenia
Timeframe: Baseline, 24 months
Prodromal Questionnaire - Brief
Timeframe: Baseline
Structured Interview for Prodromal Symptoms (SIPS) Negative/Disorganized Subscales
Timeframe: Baseline
The Adolescent Alcohol and Drug Involvement Scale
Timeframe: Baseline
Assessment of Educational Attainment
Timeframe: Baseline
Social Responsiveness Scale - Long Form
Timeframe: Baseline
Columbia Impairment Scale
Timeframe: Baseline
Global Functioning: Social and Role Scales - Brief
Timeframe: Baseline
Self-report World Health Organization - Disability Assessment Schedule
Timeframe: Baseline
Health and Social Service Utilization measure
Timeframe: 6 months
Transition Readiness Assessment Questionnaire
Timeframe: 6 months
Internet Addiction Test
Timeframe: Baseline
Parent Child Internet Addiction Test
Timeframe: Baseline
Leisure Time Questionnaire
Timeframe: Baseline, 6 months
MRI Scan
Timeframe: Baseline
Edinburgh Handedness Inventory - Brief
Timeframe: Baseline
The Snellen Chart
Timeframe: Baseline
Toolbox Dimensional Change Card Sort Task
Timeframe: Baseline
Toolbox Flanker Task
Timeframe: Baseline
Toolbox List Sorting Working Memory Test
Timeframe: Baseline
Toolbox Oral Reading Recognition Task
Timeframe: Baseline
Toolbox Pattern Comparison Processing Speed Test
Timeframe: Baseline
Toolbox Picture Sequence Memory Test
Timeframe: Baseline
Toolbox Picture Vocabulary Task
Timeframe: Baseline
Rey Auditory Verbal Learning Test
Timeframe: Baseline
Wechsler Intelligence Test for Children-V Matrix Reasoning
Timeframe: Baseline
Little Man Task
Timeframe: Baseline
Delay Discounting Task
Timeframe: 6 months
Emotional Stroop Task
Timeframe: 6 months
Penn Emotion Differentiation Task
Timeframe: 6 months
The Awareness of Social Inference Test (TASIT) - Short Version
Timeframe: 6 months
Parental Bonding Instrument
Timeframe: Baseline
Personality Inventory for DSM-5 Faceted Brief Form
Timeframe: 6 months
Competitive Sports Questionnaire
Timeframe: 6 months
International Physical Activity Questionnaire
Timeframe: 6 months
Pain Questionnaire
Timeframe: 6 months
Puberty Development Scale
Timeframe: 6 months
Social Media Addiction Questionnaire
Timeframe: Baseline
Acculturation Questionnaire
Timeframe: 6 months
Mexican American Cultural Values Scale
Timeframe: 6 months
Multigroup Ethnic Identity-Revised
Timeframe: 6 months
Vancouver Index of Acculturation - Short
Timeframe: 6 months
Parental Monitoring
Timeframe: 6 months
Prosocial Scale from the Strengths and Difficulties Questionnaire
Timeframe: 6 months
Conflict Behavior Questionnaire
Timeframe: 6 months
Gender Dysphoria Questionnaire for Adolescents and Adult
Timeframe: 6 months
Personal Attributes Questionnaire
Timeframe: 6 months
Adverse Life Events Scale
Timeframe: 6 months
Childhood Trauma Questionnaire - Short Form
Timeframe: 6 months
Connor-Davidson Resilience Scale
Timeframe: 6 months
Everyday Discrimination Scale
Timeframe: 6 months
Life Events Checklist
Timeframe: 6 months
Inventory for School Risk and Protective Factors
Timeframe: 6 months
Neighbourhood Safety and Crime Scale
Timeframe: 6 months
3-Digit Postal Codes
Timeframe: Baseline
Parent General Behaviour Inventory-10 Mania
Timeframe: Baseline, 3 months, 6 months, 12 months, 18 months, 24 months, 30 months, 36 months, 42 months
Video Game Addiction Questionnaire
Timeframe: Baseline
Student Adaptation to College Questionnaire
Timeframe: Baseline