Evacuation of Lobar Intracranial Hemorrhage Using Microsurgical Technique (ELIMINATE) (NCT07697742) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Evacuation of Lobar Intracranial Hemorrhage Using Microsurgical Technique (ELIMINATE)
Canada27 participantsStarted 2026-09-01
Plain-language summary
ELIMINATE is a cohort study, phase 2A, designed to determine whether a standardized microsurgical procedure to evacuate spontaneous lobar intracranial hemorrhage (ICH) is feasible, safe and surgically efficacious in achieving a postoperative residual ICH volume \<15cc on 24-hour postoperative CT imaging.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* • Adults \> 18 years
* CT evidence of acute, spontaneous lobar ICH defined as located \<1cm from the cortical surface
* ICH volume is \>30cc but \<80cc as measured by (length x width x height)/2
* GCS 5-14 at presentation
* NIHSS \>5
* Surgery deemed to be feasible within 16h of symptom onset
Exclusion Criteria:
* • Underlying secondary etiology (AVM, tumor, etc. if known or identifiable acutely)
* Intraventricular extension estimated to involve \>50% of the lateral ventricle
* Preoperative disability that will affect outcome as measured by modified Rankin Scale score (mRS\>1 at baseline)
* Individuals presenting with GCS \<5 at presentation
* Primary basal ganglia hemorrhage with lobar extension
* End-stage organ failure or life expectancy \<6 months
* For patients in whom the treating clinical team elects to proceed with surgical evacuation as part of clinical care, a standardized evacuation of the hematoma will be performed using neuronavigation for optimal craniotomy planning, microsurgical technique and SmartForceps System for quantifiable intraoperative data.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Recruitment rate
Timeframe: Quarterly from study onset through study completion with the final recruitment rate recorded at the end of study; total time 12 months