Respiratory and Relaxation Training in Lower Extremity Lymphedema (NCT07697482) | Clinical Trial Compass
RecruitingNot Applicable
Respiratory and Relaxation Training in Lower Extremity Lymphedema
Turkey (Türkiye)60 participantsStarted 2026-03-01
Plain-language summary
This randomized controlled trial aims to investigate the effectiveness of respiratory and relaxation training added to standard complex decongestive therapy (CDT) on muscle oxygenation, functional capacity, and limb volume in patients with lower extremity lymphedema. Participants will be randomly assigned to receive either standard CDT alone or CDT combined with respiratory and relaxation exercises. Outcomes will be assessed before treatment, immediately after treatment, and two months after completion.
Who can participate
Age range
18 Years – 65 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Female patients aged 18 years or older.
* Clinically diagnosed with secondary lower extremity lymphedema.
* Presence of lower extremity lymphedema for at least 3 months.
* Able to stand and walk independently to complete the Six-Minute Walk Test.
* Willing and able to provide written informed consent.
Exclusion Criteria:
* Acute cellulitis or other active infection within the previous 2-4 weeks.
* Current or recent deep vein thrombosis (DVT) or uncontrolled peripheral vascular disease.
* Severe cardiovascular, pulmonary, orthopedic, or neurological conditions that could interfere with participation or outcome assessments.
* Pregnancy.
* Skin lesions or irritation preventing placement of the near-infrared spectroscopy (MOXY) sensor.
* Inability to comply with the study protocol or follow-up assessments.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Muscle Oxygen Saturation
Timeframe: Baseline, immediately after 15 treatment sessions, and 2-month follow-up