The aims of the current study are: 1. Evaluation of the clinical efficacy of local delivery of nanoemulsion gel containing Centella asiatica extract as an adjunct to conventional non-surgical periodontal therapy in periodontitis patients. 2. Evaluation of the antioxidant effect of this treatment by the assessment of nuclear factor erythroid 2-related factor 2 (NrF2) and glutathione peroxidase 1 (GPX1) in the gingival crevicular fluid (GCF) samples.
Age range
25 Years – 55 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Plaque Index
Timeframe: Baseline and 3 months (Groups 1 and 2); baseline only (Group 3)
Gingival Index
Timeframe: Baseline and 3 months (Groups 1 and 2); baseline only (Group 3)
Gingival Bleeding Index
Timeframe: Baseline and 3 months (Groups 1 and 2); baseline only (Group 3)
Periodontal Probing Depth (PPD)
Timeframe: Baseline and 3 months (Groups 1 and 2); baseline only (Group 3)
Clinical Attachment Level (CAL)
Timeframe: Baseline and 3 months (Groups 1 and 2); baseline only (Group 3)