Phosphatidylserine, Taurine, and Caffeine for Cognitive Fatigue in Professional Football Players (NCT07696052) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Phosphatidylserine, Taurine, and Caffeine for Cognitive Fatigue in Professional Football Players
Poland62 participantsStarted 2026-08
Plain-language summary
This randomized, double-blind, placebo-controlled, parallel-group trial will evaluate the effects of 28 days of taurine-caffeine supplementation with or without phosphatidylserine on neurocognitive fatigue resistance, visual search efficiency, and football-specific tactical decision-making in professional male football players. Sixty-two male outfield football players from two professional clubs will be randomized to placebo, taurine plus caffeine, or taurine plus caffeine plus phosphatidylserine. Laboratory and field-based outcomes will be assessed at baseline and after the supplementation period.
Who can participate
Age range
18 Years – 37 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Male professional outfield football players aged 18 to 37 years.
* First-team players or selected U19 players aged 18 years or older who are regularly integrated into first-team training.
* Regular participation in club training.
* At least 5 years of systematic football training experience.
* Free from injury or illness limiting full participation in training and testing.
* Normal or corrected-to-normal vision.
* Ability to complete the laboratory and field-based testing procedures.
* Written informed consent provided before participation.
Exclusion Criteria:
* Goalkeepers.
* Current injury or illness limiting full participation in testing.
* Neurological disease.
* Recent concussion or head trauma.
* Uncorrected visual impairment.
* Use of phosphatidylserine, nootropic agents, or strong stimulants during the previous 4 weeks.
* Non-standard caffeine intake on testing days.
* Failure to comply with pre-test standardization procedures.
* Failed eye-tracker calibration.
* Loss of more than 30% of gaze data during the football-specific decision-making task.
* Withdrawal of consent.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Tactical Inhibitory Decision Accuracy Under Neurocognitive Load
Timeframe: Baseline and 28 days of supplementation