Exosome Therapy for Male Androgenetic Alopecia (NCT07693244) | Clinical Trial Compass
RecruitingPhase 2
Exosome Therapy for Male Androgenetic Alopecia
China120 participantsStarted 2026-04-30
Plain-language summary
The goal of this clinical trial is to learn if local scalp injection of human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exos) can treat androgenetic alopecia (AGA) in male patients with AGA.
The main question it aims to answer is:
Does hUCMSC-Exos injection improve hair regrowth compared with placebo?
Researchers will compare hUCMSC-Exos injection to placebo injection to see if hUCMSC-Exos leads to superior efficacy in hair follicle regeneration, as measured by changes in hair density, hair thickness, and patient-reported outcomes.
Participants will:
Receive randomized, double-blinded local scalp injections of either hUCMSC-Exos or placebo
Attend scheduled follow-up visits for hair assessment and safety monitoring
Undergo photography, trichoscopy, and complete quality-of-life or psychosocial burden questionnaires as applicable
Who can participate
Age range
18 Years – 55 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Male subjects aged 18 to 55 years;
. Diagnosis of androgenetic alopecia classified as Norwood-Hamilton grade III-V;
. Stable pattern of hair loss for at least 6 months prior to screening;
. Willingness to refrain from using any other hair loss treatments during the study period and for 6 months after completion of treatment.
Exclusion criteria
. Other types of alopecia, including alopecia areata, cicatricial alopecia, or telogen effluvium;
. Use of minoxidil, finasteride, spironolactone, or other hair growth-related medications within 1 year prior to screening;
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Hair Density From Baseline to Week 24
Timeframe: Baseline to Week 24
2
Change in Modified Global Photographic Assessment (MGPA) Score From Baseline to Week 24