Sex-Difference in Response to Resistance Exercise and Training Given the importance of muscular strength for athletic performance as well as for daily activities in the general population-including clinical populations-and the lack of data in both men and women, the aim of this study is to compare neuromuscular, intramuscular, and systemic adaptations in men and women in response to both acute and chronic resistance exercise. Specifically, the investigators will test the hypotheses that: the neuromuscular response to resistance exercise, including corticospinal excitability and motor unit activation patterns, differs between men and women; the hormonal response and exosome release following resistance exercise are reduced in women compared to men. Participants (n = 15 per group) will follow a supervised resistance training program for 8 weeks. Neuromuscular function of the knee extensor muscles, body composition, intramuscular adaptations, as well as blood profiles (hormonal and metabolic) and exosomes will be assessed before and after a single resistance exercise session and after the training period. This protocol will allow determination of both the acute and long-term effects of resistance exercise. Women's participation in sports is increasing, yet research in this area remains very limited. This project aims to better understand the mechanisms by which resistance training-a non-pharmacological and low-cost strategy-may induce different adaptations in men and women, and, where appropriate, to contribute to the development of sex-specific recommendations to maximize the health benefits of resistance training.
Age range
18 Years – 40 Years
Sex
ALL
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Sex differences in protein expression of muscle mass regulation pathways assessed by western blot
Timeframe: Throughout the entire study, during approximately 11 months
Sex differences in mRNA levels in muscle mass regulation pathways assessed by RT-qPCR
Timeframe: Throughout the entire study, during approximately 11 months
Sex differences in metabolic status assessed by blood biomarkers
Timeframe: Throughout the entire study, during approximately 11 months
Sex differences in hormonal status assessed by blood biomarkers
Timeframe: Throughout the entire study, during approximately 11 months
Sex differences in extracellular vesicles regulation assessed by nanoparticle tracking analysis
Timeframe: Throughout the entire study, during approximately 11 months
Sex differences in extracellular vesicles regulation assessed by proteomic analysis
Timeframe: Throughout the entire study, during approximately 11 months