Dyclonine vs. Tetracaine for Local Anesthesia in Unsedated Gastroscopy (NCT07691346) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Dyclonine vs. Tetracaine for Local Anesthesia in Unsedated Gastroscopy
China208 participantsStarted 2026-07-01
Plain-language summary
Gastroscopy is a key diagnostic approach for upper gastrointestinal diseases, but pharyngeal passage of the gastroscopy often causes participants' discomfort. Topical pharyngeal anesthetics are routinely used to alleviate such discomfort. Dyclonine hydrochloride mucilage and tetracaine hydrochloride jelly are the two most commonly used topical pharyngeal anesthetics in clinical practice. Although both agents are widely used, their comparative efficacy in unsedated gastroscopy remains unclear, and high-quality evidence is scarce. This study aims to compare their anesthetic efficacy,participant comfort, and safety.
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18-75 years, of either sex;
* Scheduled for an unsedated gastroscopy;
* American Society of Anesthesiologists (ASA) physical status class I or II;
* Able to understand and cooperate with Visual Analogue Scale (VAS) comfort assessment;
* Willing to provide written informed consent voluntarily.
Exclusion Criteria:
* Known allergy to the study agents;
* Severe cardiopulmonary disease or hepatic/renal insufficiency;
* Long-term use of sedatives or analgesics, or history of alcohol abuse;
* Pregnancy or lactation;
* Dysphagia or trismus (limited mouth opening);
* Contraindications to upper gastrointestinal endoscopy, including acute perforation and active massive bleeding;
* Mental or cognitive disorders that may preclude cooperation with the procedure;
* Scheduled for therapeutic endoscopic procedures with an anticipated procedure time exceeding 15 minutes;
* Altered upper gastrointestinal anatomy due to prior total gastrectomy, esophagectomy, or subtotal gastrectomy.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Visual Analogue Scale(VAS) Score
Timeframe: Within 5 minutes after completion of gastroscopy
Trial details
NCT IDNCT07691346
SponsorGeneral Hospital of Shenyang Military Region