Effect of Knee Position on Muscle Loss During Leg Immobilization (NCT07690150) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Effect of Knee Position on Muscle Loss During Leg Immobilization
30 participantsStarted 2026-08-01
Plain-language summary
This study looks at what happens to leg muscles when the knee is kept straight or bent during five days of wearing a brace. We want to find out if keeping the knee bent (so the thigh muscle is stretched) helps prevent muscle loss compared to keeping the knee straight. Thirty healthy adults will take part. They will wear a knee brace for five days and have several tests before and after, including scans, blood samples, and small muscle samples. The results may help doctors find better ways to protect muscles when people cannot move, for example after surgery or illness.
Who can participate
Age range
18 Years – 40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Healthy males and females
* Aged from 18-40 years at the time of signing informed consent
* 18.5 \< BMI \< 30 kg·m-2
* Must be willing and able to communicate and participate in the whole study
Exclusion Criteria:
* Smoking
* Diabetes (Type 1, Type 2, or genetic form of diabetes)
* Any diagnosed cardiovascular (heart) disease or high blood pressure (≥140 mmHg systolic and/or ≥90 mmHg diastolic)
* Chronic use of any prescribed or over the counter pharmaceuticals that may modulate muscle protein metabolism (excluding oral contraceptives and contraceptive devices).
* A personal or family history of thrombosis, epilepsy, seizures or schizophrenia.
* Prone to keloid forming (i.e. hyperplastic growth of scars).
* Any known disorders in muscle metabolism
* Regular use of dietary protein and/or amino acid supplements (\>3 times per week)
* Currently involved in a structured progressive resistance training programme (\>3 times per week)
* Known allergy to lidocaine
* Known severe kidney problems
* Allergy to one or multiple amino acids
* Recent (within the last 6 months) or current musculoskeletal injury (e.g. leg fracture)
* Having received or ingested a stable isotope tracer containing 15N in the past
* Contra-indications for MRI such as incompatible metal objects in the body and claustrophobia.
* Currently taking part in other scientific research
* Pregnant or breastfeeding
* Unable to give consent
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Muscle protein net balance (MPNB)
Timeframe: Baseline to 3 hours after tracer infusion