Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT): Open Label (NCT07689773) | Clinical Trial Compass
RecruitingPhase 2
Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT): Open Label
United States60 participantsStarted 2026-07-10
Plain-language summary
Smell dysfunction significantly impacts quality of life and safety, with limited effective treatments. This open-label study evaluates the preliminary efficacy of combining non-invasive trigeminal nerve stimulation (TNS) with standard smell training (ST) to improve olfactory function. Participants will complete 8 weeks of at-home treatment and attend three in-person visits for assessment. Improvements in smell, mood, sleep, and quality of life will be measured.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18-80
* Self-reported or medically documented smell loss
* Treatment-seeking for their smell loss
* Naïve to TNS
* Able to comprehend English and provide informed consent
Exclusion Criteria:
* Medical Records not available to confirm eligibility
* Documented/Suspected head injury (e.g. sport, accident, blast exposure)
* Neurological disorder (e.g. epilepsy, neurodegenerative disorder)
* Serious mental illness (e.g. schizophrenia, bipolar disorder)
* Suicidal ideation within the last month
* Current (≤6 months) and/or heavy cigarette smokers (i.e. ≥ 10 pack-years)
* Oral/nasal steroids or other intranasal medications
* Immunomodulatory medications
* Pregnant or trying to become pregnant
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Psychophysical Olfactory Function from Baseline to 4 and 8 Weeks
Timeframe: 8 weeks
2
Change in Perceived Intensity of Odorants from Baseline to 4 and 8 Weeks
Timeframe: 8 weeks
3
Change in Perceived Hedonics of Odorants from Baseline to 4 and 8 Weeks
Timeframe: 8 weeks
4
Change in Olfactory-related Quality of Life from Baseline to 4 and 8 Weeks
Timeframe: 8 weeks
5
Change in Impact of Olfactory Loss from Baseline to 4 and 8 Weeks