ASV and Targeted Fluid Resuscitation in Severe Burns (NCT07689097) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
ASV and Targeted Fluid Resuscitation in Severe Burns
Ukraine100 participantsStarted 2026-09-23
Plain-language summary
This prospective cohort study will evaluate the use of Adaptive Support Ventilation (ASV) together with targeted fluid resuscitation in adult patients with severe burn injuries requiring mechanical ventilation in the intensive care unit.
Patients with extensive burns often develop respiratory failure and require both invasive mechanical ventilation and large-volume fluid resuscitation during the first days after injury. The study will assess whether the combination of ASV and targeted fluid resuscitation is associated with improved oxygenation, respiratory mechanics, fluid balance, and early clinical outcomes during the first 72 hours of intensive care.
Clinical data, ventilatory parameters, laboratory results, hemodynamic variables, and fluid resuscitation characteristics will be collected as part of routine clinical care. The findings may help optimize early intensive care management for patients with severe burn injuries and improve future treatment strategies.
Who can participate
Age range
18 Years – 50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 18 years or older.
* Hospital admission with severe burn injury involving ≥20% total body surface area (TBSA).
* Requirement for invasive mechanical ventilation within 24 hours after admission to the intensive care unit.
* Expected need for mechanical ventilation for at least 48 hours.
* Treatment with Adaptive Support Ventilation (ASV) and targeted fluid resuscitation according to institutional protocols.
* Written informed consent provided by the patient or legally authorized representative, in accordance with local regulations.
Exclusion Criteria:
* Age younger than 18 years.
* Burn injury involving \<20% TBSA.
* Mechanical ventilation initiated more than 24 hours after ICU admission.
* Pregnancy.
* Pre-existing chronic dependence on invasive mechanical ventilation.
* Severe traumatic brain injury requiring a specific ventilation strategy.
* Terminal illness with an expected survival of less than 24 hours.
* Enrollment in another interventional clinical trial that may influence study outcomes.
* Inability to obtain essential clinical data required for study analysis.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Oxygenation Index During the First 7 Days
Timeframe: Baseline, 24 hours, 48 hours, 72 hours, and day 7 after ICU admission
Trial details
NCT IDNCT07689097
SponsorUkrainian Society of Regional Anesthesia and Pain Therapy