Predicting Worsening Acute Kidney Injury With a Water-Pill (Furosemide) Test and Blood Markers in… (NCT07688733) | Clinical Trial Compass
CompletedNot Applicable
Predicting Worsening Acute Kidney Injury With a Water-Pill (Furosemide) Test and Blood Markers in Patients With Low Albumin
Mexico55 participantsStarted 2022-06-04
Plain-language summary
The goal of this clinical trial is to learn if serum biomarkers can better predict worsening of acute kidney injury (AKI) compared to the Furosemide Stress Test (FST) in adult patients with low albumin levels (hypoalbuminemia) admitted to an intensive care unit (ICU). The main questions it aims to answer are:
Can serum biomarkers predict progression to severe AKI (stage 3) better than the Furosemide Stress Test in patients with low albumin levels? Is there a relationship between serum biomarkers levels and serum albumin levels in these patients?
Researchers will compare serum biomarkers levels and FST results to see which test more accurately identifies patients at risk of developing severe AKI.
Participants will:
Provide a sample for serum biomarkers measurement at study entry Receive a single intravenous dose of furosemide (a diuretic medication) to assess kidney function Have their urine output monitored for 6 hours after the furosemide dose Be followed for 15 days to track kidney function, need for dialysis, and survival
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18 years or older
* Serum albumin \< 3 g/dL (hypoalbuminemia)
* AKI diagnosed per KDIGO 2012 criteria, stage 1 or 2
* Adequate fluid resuscitation at discretion of treating nephrologist
* Cellular casts in urinary sediment (George Washington Urine Sediment Score \> 2) or fractional excretion of sodium (FENa) \> 1%
* Foley catheter in place
* Written informed consent obtained
Exclusion Criteria:
* Age under 18 years
* Pregnancy
* Obstructive urinary pathology
* Active bleeding
* Allergy or hypersensitivity to loop diuretics
* AKI stage 3 (KDIGO) at enrollment
* Inadequate fluid resuscitation prior to the stress test
* Known chronic kidney disease with eGFR \< 30 mL/min/1.73 m² (CKD-EPI equation)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study used a furosemide stress test combined with blood markers to predict worsening kidney injury in patients with low albumin — has my doctor seen this approach used, and could it change how my kidney function is being monitored right now?
2Since this trial is already completed, have the results been published, and if so, what did they find about whether the furosemide test or blood markers accurately predicted who progressed to the most severe stage of acute kidney injury?
3My albumin levels are relevant to this study — does my doctor know my current albumin level, and could low albumin be affecting how my kidneys are responding to any diuretics I'm already taking?
4The trial focused on predicting progression to Stage 3 acute kidney injury, which is the most serious category — based on where I am right now, does my doctor think I'm at risk of reaching that stage, and how would that change my treatment plan?
5Are there any standard clinical tools or tests similar to what this trial studied that my care team is already using, or would it be worth asking for a referral to a specialist who follows this kind of research?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.