CBP-0276 to Reduce Opioid Use in Adults Undergoing Major Orthopedic Surgery

Inclusion criteria: * Men or women * Age between 40 and 75 years (inclusive) * Body weight between 50 and 90 Kg * Post-surgical patient of major orthopedic surgery, with opioid treatment (oxycodone) at discharge by treating physician * Physical status of ASA I to III * Be able and willing to read, understand, sign, and date the Informed * Consent Form prior to entering the study. * Woman of childbearing age with effective contraception, not pregnant, not on breastfeeding, not pregnancy plans during the development of the study, postmenopausal, defined by cessation of menstruation for at least 12 consecutive months and confirmed by serum FSH levels \> 40 mIU/mL and estradiol \< 20 pg/mL or surgically sterile (with hysterectomy, bilateral salpingectomy, or bilateral oophorectomy) and not undergoing in vitro fertilization or other fertility treatments) * Men agreed to use contraception or remain abstinent (when this is the subject's usual and preferred lifestyle)Be willing to complete all study visits and procedures. Exclusion criteria: * History of respiratory depression, severe bronchial asthma, chronic obstructive pulmonary disease, or acute and/or severe hypercepnia and cor pulmonale. * History of gastrointestinal motility disorders (e.g., severe reflux esophagitis, gastroparesis, severe irritable bowel syndrome, active inflammatory bowel disease, and paralytic ileus). * History of depression, seizures, and epilepsy. * Uncontrolled hypertension: systolic BP ≥160 mmHg or d…