RecruitingNot Applicable

Hyaluronic Acid and I-PRF Mixture for TMJ Disc Displacement Management

Egypt72 participantsStarted 2026-01-06

Plain-language summary

The aim of this study is to evaluate the efficacy of hyaluronic acid and I-PRF mixture for intra-articular injection following arthrocentesis in the management of TMJ reducible disc displacement.

Who can participate

Age range

18 Years – 45 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Age: 18 - 45 years.
. Patients with disc displacement with reduction in any of the TMJs.
. arthralgia.
. Limited unassisted mouth opening.
. Co-operative patients.

Exclusion criteria

. Patients with previous history of TMJ minimally invasive interventions.
. Patients with autoimmune or connective tissue diseases affecting the joints.
. Patients with neurological disorders.
. Patients with a history of condylar fractures or ankylosis.
. Patients with psychological problems.
. Patients receiving non-steroidal anti-inflammatory drugs within 48 hours preoperatively, or systemic use of corticosteroids within 2 weeks.
. Patients on anticoagulants, suffering from platelet function disorders or fibrinogen deficiency.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Intensity of pain

Timeframe: preoperative, one week, one month, 3 months and 6 months

Maximum interincisal opening, lateral and protrusive movements

Timeframe: preoperative, one week, one month, 3 months and 6 months

Trial details

NCT IDNCT07683650

SponsorMansoura University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12

Contact for this trial

Nada Hamed

00201119659235 hamednada99@mans.edu.eg

View on ClinicalTrials.gov More TMJ Disc Displacement With Reduction trials