The goal of this clinical trial is to learn whether a single dose of XBD173, a medicine that binds to a protein called the 18 kiloDalton Translocator Protein (TSPO), affects how the body processes glucose in healthy volunteers aged 18 to 75 years. The main questions it aims to answer are: * Does a single dose of XBD173 change fasting blood glucose levels compared with placebo? * Does a single dose of XBD173 change blood glucose levels after participants drink a glucose solution compared with placebo? Researchers will compare XBD173 with a placebo, which does not contain the active medicine, to see whether activating TSPO affects glucose metabolism in the fasting state and after a glucose drink. Participants will: * Attend a screening visit to confirm eligibility, including a medical history, physical examination and blood tests. * Attend four study visits after fasting overnight: two visits involving a glucose drink and two visits without a glucose drink. * Receive a single oral dose of XBD173 at some visits and placebo at other visits. The order will be randomised, and neither participants nor the study team conducting the assessments will know which treatment is given during each visit. * Have repeated blood samples taken through a cannula to measure glucose, insulin and other markers related to metabolism and inflammation. * Have resting energy use measured by breathing under a transparent canopy connected to a standard metabolic measurement device. * Have blood pressure, heart rate, height and weight measured. * Undergo measurement of blood vessel function using a cuff.
Age range
18 Years – 75 Years
Sex
ALL
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Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Plasma Glucose Concentration in millimoles per litre During Oral Glucose Tolerance Test
Timeframe: Blood samples will be collected at 60, 30, and 10 minutes before the oral glucose tolerance test; at the time of the test; and at 30, 60, 90, 120, 150, and 180 minutes after the test. The oral glucose tolerance test will be administered at 0 minutes.
Fasting Plasma Glucose Concentration in millimoles per litre After XBD173 or Placebo Administration
Timeframe: Blood samples will be collected at 10 minutes before XBD173 or placebo administration, at administration, and at 30, 60, 90, 120, 150, 180, 210, and 240 minutes after administration.