Alzheimer's disease is a condition that affects the brain and is associated with the build-up of waste substances that can damage brain cells. Scientists have recently discovered a natural drainage and cleaning system around the brain, called the meningeal lymphatic system, which may help remove these waste products. Researchers believe that this brain drainage system is connected to lymph nodes located in the neck. However, this connection has not yet been clearly demonstrated in humans because it is difficult to study. The purpose of this study is to investigate how fluid drains from the brain to the lymph nodes in the neck. To do this, researchers will use a fluorescent dye called indocyanine green, which can be seen with a special camera. The study will be carried out in potential organ donors who have been authorized for organ donation. The researchers will record images and videos to observe how the dye moves, how long it takes to reach the lymph nodes, whether the drainage is similar on both sides of the body, and which lymph nodes are involved. A better understanding of these drainage pathways may help researchers develop and improve future treatments for Alzheimer's disease and other neurological disorders.
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
presence or absence of bilateral and symmetrical distribution of indocyanin green drainage
Timeframe: baseline
Assessment of the Indocyanin Grees pathways in its migration through the lymph channels to the cervical region.
Timeframe: baseline
Cervical ganglion levels to which the ICG migrates.
Timeframe: baseline