IL-6 and Cortisol Responses to Cycling Exercise (NCT07681362) | Clinical Trial Compass
CompletedNot Applicable
IL-6 and Cortisol Responses to Cycling Exercise
Turkey (Türkiye)27 participantsStarted 2025-05-05
Plain-language summary
This study aimed to investigate salivary interleukin-6 (IL-6) and cortisol responses following short-term and long-term cycling exercise in team athletes with different cardiorespiratory fitness levels. Participants completed a Wingate anaerobic cycling test and a YMCA submaximal cycling test in a randomized crossover design separated by a seven-day washout period. Saliva samples were collected before exercise, immediately after exercise, and 30 minutes after exercise to determine IL-6 and cortisol concentrations. The study also examined whether cardiorespiratory fitness level influenced the magnitude of these physiological responses.
Who can participate
Age range
18 Years – 35 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Team athletes aged 18 to 35 years Participation in organized team sports (e.g., volleyball, basketball, soccer, or handball) Minimum of 3 training sessions per week, with each session lasting at least 1 hour Sports participation history of at least 2 years Apparently healthy and free from known cardiovascular, metabolic, endocrine, or respiratory diseases Willingness to provide written informed consent
Exclusion Criteria:
Current musculoskeletal injury or illness affecting exercise performance Use of medications known to influence hormonal or inflammatory responses Smoking or use of tobacco products Acute infection within the previous two weeks Failure to complete both exercise testing sessions Failure to comply with pre-test instructions
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Salivary Cortisol Response
Timeframe: Pre-exercise, immediately post-exercise, and 30 minutes post-exercise