This study to find out whether a type of non-invasive electrical brain stimulation called transcranial electrical stimulation with temporal interference (TES-TI) can temporarily change brain activity during sleep-especially sleep spindles (brain rhythms in the \~8-16 Hz range). The investigators are focusing on the thalamus, a deep brain region that helps coordinate brain activity during non-REM sleep. Sleep spindles are often reduced in schizophrenia, so this study is to see whether TES-TI can change spindle activity in individuals with schizophrenia spectrum disorders (SSD) and in healthy adults. To study this, a structural MRI scan will be used to customize where the stimulation electrodes are placed, and then TES-TI will be applied during one of two overnight sleep lab visits while brain activity is recorded with high-density EEG and standard sleep sensors. The other overnight is a baseline/control night during which only sham stimulation is delivered. The goal is to determine whether TES-TI during sleep can increase spindle-frequency activity in this population.
Age range
18 Years – 50 Years
Sex
ALL
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Change in spindle-frequency activity (8-16 Hz spectral power)
Timeframe: data collected over two overnight visits separated by at least 2 weeks during stable N2 sleep
Change in spindle density
Timeframe: data collected over two overnight visits separated by at least 2 weeks during stable N2 sleep
Change in spindle amplitude
Timeframe: data collected over two overnight visits separated by at least 2 weeks during stable N2 sleep
Change in spindle duration
Timeframe: data collected over two overnight visits separated by at least 2 weeks during stable N2 sleep
Change in spindle topography
Timeframe: data collected over two overnight visits separated by at least 2 weeks during stable N2 sleep