RESISTANCE TRAINING AND CAPILLARIZATION - ROLE ON THE ANABOLIC RESPONSE IN OLDER ADULTS (NCT07680036) | Clinical Trial Compass
CompletedNot Applicable
RESISTANCE TRAINING AND CAPILLARIZATION - ROLE ON THE ANABOLIC RESPONSE IN OLDER ADULTS
Italy30 participantsStarted 2024-01-01
Plain-language summary
The goal of this clinical trial is to learn how muscle capillaries influence the response to resistance exercise training in older adults. The study will include older men and women who may experience age-related declines in muscle mass and function. The main questions it aims to answer are:
* Does baseline muscle capillarization influence the increase in muscle size and function following resistance exercise training?
* Can resistance exercise stimulate the formation of new capillaries in older adults with lower baseline capillarization, and how is this related to muscle growth?
Participants will:
* Undergo assessments of muscle structure, capillarization, and physical function before and after the intervention.
* Participate in a supervised resistance exercise training program.
* Provide muscle samples and other physiological measurements to evaluate changes in muscle growth and blood vessel formation.
Researchers will analyze the relationship between baseline muscle capillarization, exercise-induced angiogenesis, and improvements in muscle mass and function to better understand why some older adults respond more effectively to resistance exercise than others.
Who can participate
Age range
65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥ 65 years
* Body Mass Index (BMI) \>18 and \<30 kg/m²
* Stable body weight for at least 3 months prior to enrollment
Exclusion Criteria:
* Prediabetes or diabetes according to ADA criteria
* Chronic diseases, including cardiovascular, liver, respiratory diseases, or cancer
* Acute inflammatory conditions, infections, or other clinically significant illnesses
* Regular participation in vigorous physical activity (≥2 sessions per week)
* Current or recent (within the previous 3 months) treatment with steroid medications
* Regular use of protein supplements
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.