Effects of Inter-Set Rest Intervals on Muscle Damage After Flywheel Exercise in Untrained Men (RCT) (NCT07679971) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Effects of Inter-Set Rest Intervals on Muscle Damage After Flywheel Exercise in Untrained Men (RCT)
Brazil30 participantsStarted 2026-06
Plain-language summary
This randomized parallel-group clinical trial will compare the acute effects of three different inter-set rest intervals during a single lower-limb flywheel resistance exercise session in untrained men. Participants will be randomly allocated to one of three groups: 1-minute, 2-minute, or 3-minute inter-set rest interval. The primary outcome will be the change in maximal voluntary isometric contraction of the knee extensors 48 hours after exercise. Secondary outcomes will include mechanical variables during the exercise session, countermovement jump performance, knee flexor maximal voluntary isometric contraction, muscle soreness, pressure pain threshold, range of motion, ultrasound-derived muscle thickness and echo intensity, perceived exertion, perceived discomfort, perceived recovery status, creatine kinase, and lactate dehydrogenase.
Who can participate
Age range
18 Years – 40 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age between 18 and 40 years;
* Apparently healthy and clinically able to perform physical exercise;
* No participation in structured resistance training during the previous 6 months;
* Agreement to comply with all study visits and procedures;
* Signed informed consent form.
Exclusion Criteria:
* History of lower-limb musculoskeletal injury or surgery that may impair performance or safety during the proposed exercise protocol;
* Current pain, injury, or functional limitation in the lower limbs;
* Use of ergogenic aids that may affect physical performance or muscle recovery;
* Use of analgesic or anti-inflammatory medication during the study period;
* Failure to attend the scheduled visits required for the primary outcome assessment.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in maximal voluntary isometric contraction of the knee extensors
Timeframe: Baseline, 10 minutes after the experimental exercise session, 48 hours after the experimental exercise session, and 96 hours after the experimental exercise session
2
Change in maximal voluntary isometric contraction of the knee flexors
Timeframe: Baseline, 10 minutes after the experimental exercise session, 48 hours after the experimental exercise session, and 96 hours after the experimental exercise session