The CPR, Pre-hospital ECPR and Early Reperfusion Study: A Target Trial Emulation (NCT07679737) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
The CPR, Pre-hospital ECPR and Early Reperfusion Study: A Target Trial Emulation
Australia250 participantsStarted 2025-01-01
Plain-language summary
CHEER4TTE is a target trial emulation, designed to simulate a randomised controlled trial by utilising data from pre-existing data sources. The aim is to determine whether prehospital ECPR for refractory out-of-hospital cardiac arrest improves the rate of survival to hospital discharge when compared to conventional cardiac arrest care.
Who can participate
Age range
18 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Witnessed cardiac arrest
* Bystander CPR
* Refractory cardiac arrest (failure to achieve sustained ROSC \>20 minutes)
* Initial cardiac rhythm VF, VT or PEA
* Within the hours of prehospital ECPR service operation
Exclusion Criteria:
* Initial cardiac rhythm asystole
* ROSC with sustained recovery
* Unable to reach the patient and commence cannulation within 45 minutes of onset of arrest
* Evidence of/suspected end-stage disease:
* severe disability impairing activities of daily living
* end-stage organ disease - cardiac, liver, lung, renal
* other life-limiting diseases, e.g. malignancy, terminal illness
* advance health care directive
* Time periods of advanced public health restrictions in Victoria and NSW due to COVID-19
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Survival to hospital discharge
Timeframe: From meeting full eligibility criteria until the date/time of death or hospital discharge, assessed up to 180 days
Trial details
NCT IDNCT07679737
SponsorAustralian and New Zealand Intensive Care Research Centre