Nanofat Injection and Fractional CO2 Laser for Post-Traumatic Atrophic Scars (NCT07679217) | Clinical Trial Compass
By InvitationNot Applicable
Nanofat Injection and Fractional CO2 Laser for Post-Traumatic Atrophic Scars
Egypt60 participantsStarted 2026-06-28
Plain-language summary
Post-traumatic atrophic scars are characterized by skin depressions caused by loss of collagen and can lead to cosmetic and psychological concerns. Several treatment options have been proposed, including fractional carbon dioxide (CO2) laser resurfacing and autologous nanofat grafting, both of which may improve scar appearance through skin remodeling and regeneration. This prospective comparative study evaluates the safety and efficacy of fractional CO2 laser alone, autologous nanofat injection alone, and combination therapy in patients with post-traumatic atrophic scars. Sixty participants were assigned to one of three treatment groups and were assessed using the Vancouver Scar Scale, physician global assessment, patient satisfaction, dermoscopic examination, and histopathological evaluation. The study aims to determine whether combining fractional CO2 laser and nanofat injection provides superior clinical and regenerative outcomes compared with either treatment alone while maintaining an acceptable safety profile.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Male or female participants aged 12 years or older.
* Presence of post-traumatic atrophic scar(s) of at least 6 months' duration.
* No scar treatment received during the previous 6 months.
* Willingness and ability to provide written informed consent (or assent with -parental/guardian consent for minors, according to local regulations).
* Willingness to comply with study procedures and follow-up assessments.
Exclusion Criteria:
* Hemoglobin \<10 g/dL.
* Active infection or viral skin disease.
* Coagulopathy or hemophilia.
* Current anticoagulant therapy.
* Diabetes mellitus.
* History of keloid formation.
* History of malignancy or prior radiation therapy.
* Immunosuppression.
* Long-term systemic corticosteroid therapy.
* Photosensitivity disorders.
* Pregnancy or breastfeeding.
* Renal or hepatic disease.
* Systemic diseases affecting wound healing.
* Thin patients with insufficient adipose tissue for adipose tissue harvesting.
* Previous scar treatment within the preceding 6 months.
* Use of systemic retinoids within the preceding 6 months. -Use of topical retinoids within the preceding 2 weeks.-
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Vancouver Scar Scale Score
Timeframe: Baseline and 3 months after completion of treatment