eCASH and Early Goal-Directed Mobilization to Prevent ICU-Acquired Weakness

Inclusion Criteria: * Patients admitted to the ICU who require invasive mechanical ventilation and have a mechanical ventilation duration of at least 48 hours. * Age 18 years or older. * Patients who are not undergoing secondary intubation. * Patients with relatively stable organ function. * Written informed consent provided by the patient's family member or legally authorized representative. Exclusion Criteria: * Patients in the acute stress phase with hemodynamic instability, including severe patient-ventilator asynchrony, severe traumatic brain injury with intracranial hypertension, status epilepticus, or after cardiopulmonary resuscitation. * Patients with severe acute respiratory distress syndrome. * Patients with neurological diseases, organic neurological lesions, or neurological injury. * Patients with a history of psychiatric disease. * Patients with complications causing altered mental status and inability to cooperate, such as hepatic encephalopathy or pulmonary encephalopathy. * Patients diagnosed with myasthenia gravis. * Patients with a history of psychoactive drug abuse, illicit drug use, or alcohol abuse.