CompletedNot Applicable

Comparing Two Agents Used to Stop Bleeding During Tonsil Removal Surgery: Adrenaline Versus Hydrogen Peroxide

Pakistan64 participantsStarted 2024-02-01

Plain-language summary

The goal of this quasi-experimental study is to compare the effectiveness of topical adrenaline and 3% hydrogen peroxide for controlling bleeding (hemostasis) during tonsil removal surgery in patients aged 5 to 18 years. The main questions it aims to answer are: 1. Which substance leads to faster bleeding control during surgery? 2. Which substance results in less total blood loss during surgery? Researchers compared the adrenaline group to the hydrogen peroxide group to see if one agent was more effective at managing bleeding than the other. Participants underwent a tonsillectomy where surgeons applied either gauze soaked in adrenaline (1:100,000 solution) or gauze soaked in 3% hydrogen peroxide to the tonsil area to stop bleeding.

Who can participate

Age range

5 Years – 18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Patients aged 5-18 years.
. Scheduled for elective tonsillectomy.
. Diagnosis of chronic or recurrent tonsillitis.
. Normal coagulation profile.
. Medically fit for general anesthesia.
. Provided informed consent (from participant, or parent/legal guardian for pediatric participants).

Exclusion criteria

. Patients with a coagulation or bleeding disorder.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Severity of intraoperative blood loss during tonsillectomy as classified by combined gravimetric and volumetric assessment.

Timeframe: Measured during the intraoperative period, specifically from the time of hemostatic agent application until the completion of the tonsillectomy procedure.

Time to achieve intraoperative hemostasis during tonsillectomy as measured in minutes.

Timeframe: Measured during the intraoperative period, specifically from the time of hemostatic agent application until the completion of the tonsillectomy procedure.

Trial details

NCT IDNCT07675278

SponsorRawalpindi Medical College

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-01-31

View on ClinicalTrials.gov More Chronic Tonsillitis trials

Plain-language summary

Who can participate

Age range

5 Years – 18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Patients aged 5-18 years.
. Scheduled for elective tonsillectomy.
. Diagnosis of chronic or recurrent tonsillitis.
. Normal coagulation profile.
. Medically fit for general anesthesia.
. Provided informed consent (from participant, or parent/legal guardian for pediatric participants).

Exclusion criteria

. Patients with a coagulation or bleeding disorder.

What they're measuring

Severity of intraoperative blood loss during tonsillectomy as classified by combined gravimetric and volumetric assessment.

Timeframe: Measured during the intraoperative period, specifically from the time of hemostatic agent application until the completion of the tonsillectomy procedure.

Time to achieve intraoperative hemostasis during tonsillectomy as measured in minutes.

Timeframe: Measured during the intraoperative period, specifically from the time of hemostatic agent application until the completion of the tonsillectomy procedure.