Interventions to Enhance Quadriceps Output After ACLR (NCT07674784) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Interventions to Enhance Quadriceps Output After ACLR
United States22 participantsStarted 2026-06
Plain-language summary
The investigators are interested in determining what treatments are effective in reducing inhibition after anterior cruciate ligament (ACL) surgery and helping people increase quadriceps strength. Two interventions that are often used clinically are neuromuscular electrical stimulation (NMES) and vibration. This is a study of how effective these treatments are, whether they work the same for everyone, and if one is better than the other. 22 participants will be enrolled and on study for 2 to 3 weeks.
Who can participate
Age range
18 Years – 40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Have undergone ACLR within the previous 4 months
* Are at least 2 months post-ACLR
Exclusion Criteria:
* A history of ACLR on both legs
* Since the most recent ACLR:
* secondary lower extremity surgery
* leg or foot fracture
* Unable to walk without an assistive device
* Pain of greater than 5/10 during quadriceps strengthening exercises with the surgical limb
* Cannot achieve 90 degrees of knee flexion with the surgical limb
* People with contraindications to NMES
* Anyone who had a previous skin reaction to NMES or attempted but could not tolerate NMES
* Peripheral neuropathy or other neurological conditions
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in knee extensor peak torque production
Timeframe: measured pre-intervention and post-intervention during each of 2, 1-hour study visits, data collection complete within 3 weeks