Not Yet RecruitingPhase 3

Efficacy of Intravenous Dexamethasone in Prolonging the Duration of Spinal Anesthesia With Chloroprocaine in Knee Arthroscopy

France60 participantsStarted 2026-09-01

Plain-language summary

Chloroprocaine is a short-acting local anesthetic that allows rapid recovery and early ambulation but is currently recommended for procedures lasting 40 minutes or less. Dexamethasone is commonly used during anesthesia for the prevention of postoperative nausea and vomiting and has also been shown to prolong the duration of analgesia and sensory block after regional anesthesia. Dexamethasone may therefore extend the duration of chloroprocaine spinal anesthesia, potentially allowing its use for longer surgical procedures while maintaining the benefits of rapid postoperative recovery. This study aims to evaluate whether intravenous dexamethasone can prolong the effects of spinal anesthesia performed with chloroprocaine in adults undergoing knee arthroscopy.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Undergoing knee arthroscopy lasting ≤ 40 minutes requiring spinal anesthesia (diagnostic arthroscopy or meniscal surgery), * Signed written informed consent form, * Affiliation to a social security system, * Negative pregnancy test on the day of procedure for non-menopausal patients. Exclusion Criteria: * Contraindications to spinal anesthesia with intrathecal chloroprocaine * History of diabetes, * Pre-existing peripheral neuropathy, * American Society of Anesthesiologists (ASA) physical status IV, * Contraindication to dexamethasone, * Hypersensitivity of any drug used in this study, * Long-term oral corticosteroid therapy, * Chronic opioid use, * Chronic pain syndromes, * Contraindications to Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) (Ketoprofen, Celecoxib) * Need for a peripheral nerve block in addition to spinal anesthesia (e.g. knee ligamentoplasty), * Mental or linguistic inability to understand the study, * Patients under legal protection (guardianship, curatorship or safeguard of justice), * Patients currently included or planning to be included in another interventional study, * Pregnant or breastfeeding women, * Women of childbearing potential not using effective contraception.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Time to regression of sensory block by two dermatomes (pin-prick test)

Timeframe: Up to 2 hours following spinal anesthesia

Trial details

NCT IDNCT07674576

SponsorCMC Ambroise Paré

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-08-31

Contact for this trial

Sébastien BLOC, MD

01 44 14 11 11 sebebloc@gmail.com

View on ClinicalTrials.gov More Knee Arthroscopy trials