Cross-System Effects of Acute Intermittent Hypercapnia-Based Interventions in PD (NCT07674264) | Clinical Trial Compass
RecruitingNot Applicable
Cross-System Effects of Acute Intermittent Hypercapnia-Based Interventions in PD
United States32 participantsStarted 2026-06-20
Plain-language summary
Parkinsonism impairs upper airway and axial motor control, leading to disordered breathing, reduced speech volume, and ineffective cough. Symptoms are poorly addressed by current therapies. This randomized pilot trial tests whether a single session of acute intermittent hypercapnic hypoxia (AIHH) or hypercapnic normoxia (AIHN) improves upper airway and axial motor function in Parkinsonism, and explores biomarker correlates of intervention responsiveness.
Who can participate
Age range
40 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. adults 40 to 75 years of age (the latter to reduce the likelihood of cardiovascular disease)
. diagnosis of idiopathic Parkinsonism with Hoehn and Yahr stages 2-4
. medically stable with physician clearance
. ability to ambulate at least 10 feet with/without assistance
. ability to follow directions
. willing to abstain from blood donation for the duration of the study
Exclusion criteria
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in speech loudness
Timeframe: baseline and 60 minutes post-intervention
2
Change in maximum phonation duration
Timeframe: baseline and 60-minutes post-intervention
3
Change in peak expiratory flow rate during voluntary cough
Timeframe: baseline and 60 minutes post-intervention
4
Change in Five-Times Sit-to-Stand performance
Timeframe: baseline and 60 minutes post-intervention
5
Change in Timed Up and Go performance
Timeframe: baseline and 60 minutes post-intervention
6
Change in fast walking speed
Timeframe: baseline and 60 minutes post-intervention
7
Correlation between blood-based biomarkers and functional outcomes
Timeframe: Baseline and 60 minutes post-intervention; genotype assessed at baseline only