Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III Periodontitis (NCT07673185) | Clinical Trial Compass
RecruitingNot Applicable
Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III Periodontitis
Egypt40 participantsStarted 2025-01-15
Plain-language summary
This randomized double-blind placebo-controlled clinical trial aims to evaluate the clinical and biochemical effects of omega-3 fatty acids combined with low-dose aspirin as an adjunct to scaling and root planing (SRP) in smoker patients with Stage III periodontitis. The study compares test and control groups regarding periodontal clinical parameters and gingival crevicular fluid interleukin-1 beta (IL-1β) levels Or other inflammatory markers that will be determined later at baseline, 3 months, and 6 months following treatment
Who can participate
Age range
30 Years – 50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* \- Male or female smokers aged 30 to 50 years.
* Diagnosed with Stage III periodontitis according to the 2017 World Workshop classification.
* Probing pocket depth (PPD) ≥ 5 mm.
* Clinical attachment loss (CAL) ≥ 5 mm.
* Presence of at least 20 natural teeth.
* Willing and able to provide written informed consent.
Exclusion Criteria:
* \- Systemic diseases affecting periodontal health.
* Pregnancy or lactation.
* Periodontal treatment within the previous 6 months.
* Use of antibiotics or anti-inflammatory drugs within the previous 6 months.
* Allergy or hypersensitivity to omega-3 fatty acids or aspirin.
* Long-term anticoagulant therapy.
* History of gastric ulcer or bleeding disorders.
* Participation in another clinical trial within the previous 3 month
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.