Predicting Local Anesthetic Success in Symptomatic Irreversible Pulpitis: A Machine Learning Study (NCT07672678) | Clinical Trial Compass
CompletedNot Applicable
Predicting Local Anesthetic Success in Symptomatic Irreversible Pulpitis: A Machine Learning Study
4,390 participantsStarted 2014-05-01
Plain-language summary
This study will develop and internally validate three machine learning models - logistic regression, random forest, and XGBoost - to predict local anesthetic (LA) success in patients undergoing endodontic treatment for symptomatic irreversible pulpitis (SIP). A large retrospective cohort of 4,390 consecutive adult patients treated at a single center (May 2014-October 2025) is being analyzed. The dataset was frozen in October 2025 for this analysis.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults (≥18 years) presenting with a clinical diagnosis of symptomatic irreversible pulpitis in a permanent tooth
* Diagnosis confirmed on the basis of patient-reported symptoms (spontaneous pain, lingering pain to thermal stimuli), clinical examination, and positive pulp sensibility testing (cold test and/or electric pulp test)
* Absence of radiographic evidence of periapical pathology
* ASA physical status I or II
* No prior local anesthetic injection for the same tooth within the preceding 24 hours
* No documented allergy or contraindication to amide local anesthetics
Exclusion Criteria:
* ASA physical status classification III or higher
* Pregnancy
* Confirmed radiographic periapical lesion or diagnosis of pulp necrosis
* Prior local anesthetic injection for the same tooth within the preceding 24 hours
* Documented allergy or contraindication to amide local anesthetics
* Age under 18 years
* Records with missing key predictor or outcome variables (9.2% of initially screened records excluded)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Local anesthetic (LA) success rate
Timeframe: 15 minutes Intraoperatively during endodontic treatment (from initiation of access cavity preparation to completion of root canal instrumentation)