Effect of Type 2 Diabetes on Biomarker Levels in Albumin Platelet-Rich Fibrin (NCT07672652) | Clinical Trial Compass
CompletedNot Applicable
Effect of Type 2 Diabetes on Biomarker Levels in Albumin Platelet-Rich Fibrin
Turkey (Türkiye)20 participantsStarted 2025-12-15
Plain-language summary
Diabetes mellitus is a metabolic disease that can negatively affect wound healing and tissue repair. Albumin platelet-rich fibrin (Alb-PRF) is a blood-derived biomaterial used in periodontal and regenerative treatments. It contains growth factors and cytokines that may support tissue healing.
The purpose of this study is to evaluate whether type 2 diabetes affects the biological composition of Alb-PRF. For this purpose, Alb-PRF samples obtained from individuals with type 2 diabetes will be compared with samples obtained from systemically healthy individuals.
A total of 20 participants will be included in the study: 10 individuals with type 2 diabetes and 10 systemically healthy individuals. Venous blood samples will be collected from each participant, and Alb-PRF will be prepared using a standardized protocol. The prepared samples will be stored at -80°C until laboratory analysis.
The levels of interleukin-6 (IL-6), epidermal growth factor (EGF), and insulin-like growth factor-1 (IGF-1) in Alb-PRF samples will be measured using an enzyme-linked immunosorbent assay (ELISA). These markers are related to inflammation, tissue repair, and wound healing. The results will help determine whether type 2 diabetes changes the cytokine and growth factor profile of Alb-PRF.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
For the type 2 diabetes group:
* Diagnosis of type 2 diabetes
* HbA1c value of at least 7%
* Age over 18 years
* Non-smoker
* No use of antibiotics, anti-inflammatory drugs, or systemic corticosteroids within the last 6 months
* Not pregnant or lactating
* Willingness to participate in the study and signing of the informed consent form
For the systemically healthy group:
* No history of diabetes or prediabetes
* Age over 18 years
* Non-smoker
* No use of antibiotics, anti-inflammatory drugs, or systemic corticosteroids within the last 6 months
* Not pregnant or lactating
* Willingness to participate in the study and signing of the informed consent form
Exclusion Criteria:
* Age under 18 years
* Pregnancy or lactation
* Use of antibiotics, anti-inflammatory drugs, or systemic corticosteroids within the last 6 months
* Smoking
* Refusal to participate in the study or not signing the informed consent form
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.