Safety and Immune Response of a Rabies Vaccine With the Essen Schedule and a Two-Dose Booster

Inclusion Criteria: * Healthy subjects aged 10-60 years as established by medical history and clinical examination * The subjects are able to understand and sign the informed consent * Female subjects aged 18-60 years must have a negative urine pregnancy test result and commit to using contraception for 2 months following the first vaccine dose in this study. * Subjects who can and will comply with the requirements of the protocol * Subjects with temperature ≤37.0°C on axillary setting Exclusion Criteria: Exclusion Criteria for the first dose: * Subject who was administered human rabies vaccine or rabies immunoglobulin. * Subject that has a medical history of any of the following: allergic history, or allergic to any ingredient of vaccine, especially allergic to neomycin. * Has been diagnosed or suspected of having an immune deficiency, autoimmune disease, or immune system disorder. * History of thyroidectomy, or thyroid disease requiring treatmentin the past 12 months * Bleeding disorder diagnosed by a doctor or significant bruising or bleeding difficulties with injections or blood draws * History of epilepsy, convulsions or convulsions, or a family history of psychosis. * Absence of spleen, functional absence of spleen, and any circumstances leading to absence of spleen or splenectomy. * Have a malignant tumor in active phase, or a tumor that have been treated but not clearly cured, or may relapse during the study period. * In the past 6 months, there have been immunosu…