CompletedNot Applicable

Energy Metabolism and Eating Behavior in Underweight and Normal-weight Individuals

Chile59 participantsStarted 2023-03-23

Plain-language summary

This study evaluates eating behavior and metabolic responses following consumption of a high-fat high-energy meal in healthy underweight and normal-weight adults. The primary research question is: Do healthy underweight individuals exhibit different eating and metabolic responses compared with normal-weight adults following consumption of a high-fat high-energy meal?

Who can participate

Age range

18 Years – 25 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria: * Men or women * Age 18-25 years * Stable body weight during the previous 6 months (±2 kg) * Healthy according to medical history and laboratory assessments * BMI: 15.0-\<18.5 kg/m2 or 20.0-\<25.0 kg/m2 Exclusion criteria: * Pregnancy or lactation * Athletes or individuals engaged in high levels of physical activity, including those participating in competitive sports, structured endurance training, or physically demanding occupations. * Cardiovascular, liver, kidney, thyroid, or other chronic diseases requiring medical treatment * Conditions affecting energy metabolism or eating behavior * Smoking or alcohol abuse * Phobia or vasovagal response associated with blood draws * Intolerance or allergy to peanuts, chocolate, eggs, or gluten * Irregular menstrual cycles (\>3 months without menstruation) * Current or previous diagnosis of eating disorders * Psychiatric disorders requiring antidepressant or psychotropic treatment Additional criterion for healthy underweight participants: * Absence of food insecurity * Low body weight not attributable to eating disorders or exercise-related behaviors

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Total ad-libitum energy intake

Timeframe: The feeding test will be conducted 6.5 hours after the high-fat, high-energy meal.

Trial details

NCT IDNCT07671105

SponsorJose Galgani

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-01-16

View on ClinicalTrials.gov More Healthy Underweight trials