Mechanical Power During Different Ventilation Modes in Laparoscopic Surgery (NCT07670494) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Mechanical Power During Different Ventilation Modes in Laparoscopic Surgery
80 participantsStarted 2026-07-01
Plain-language summary
This study investigates how different breathing machine (ventilator) settings affect the energy delivered to the lungs during surgery. Mechanical power is a measure of this energy, and high levels can sometimes lead to lung irritation. In clinical practice, a mode called Pressure-Regulated Volume Control (PRVC) is often used because it lowers the "peak" pressure in the airways, which is generally thought to be safer. However, doctors have noticed that even though the peak pressure goes down in PRVC mode, the total mechanical power displayed on the monitor might actually increase compared to the standard Volume-Controlled Ventilation (VCV) mode. In this study, patients undergoing gallbladder surgery will be monitored using both ventilation modes in a random order. The researchers will compare the machine-calculated mechanical power for both modes to see if the perceived benefit of lower peak pressure in PRVC actually results in lower overall energy transfer to the lungs.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients undergoing elective laparoscopic cholecystectomy surgery.
* Patients between 18 and 75 years of age.
* American Society of Anesthesiologists (ASA) physical status I, II or III.
* Body Mass Index (BMI) between 18.5 and 35 kg/m².
* Voluntary written informed consent for participation.
Exclusion Criteria:
* History of significant chronic obstructive pulmonary disease (COPD) or asthma.
* Previous lung resection or major thoracic surgery.
* Heavy smokers (more than 20 cigarettes per day).
* Presence of spontaneous breathing effort during mechanical ventilation.
* Conversion from laparoscopic surgery to open surgery during the procedure.
* Emergency surgery cases.
* Known pregnancy.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Device-Displayed Mechanical Power
Timeframe: At the end of a 10-minute stabilization period in each ventilation mode (VCV and PRVC).
Trial details
NCT IDNCT07670494
SponsorDr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital