Comparison of Debridement, Antibiotic, Implant Retention and Implant Exchange in Early-stage Frac… (NCT07669714) | Clinical Trial Compass
RecruitingNot Applicable
Comparison of Debridement, Antibiotic, Implant Retention and Implant Exchange in Early-stage Fracture-related Infections
Turkey (Türkiye)75 participantsStarted 2026-04-16
Plain-language summary
This study aims to compare the clinical outcomes of debridement, antibiotics, and implant retention (DAIR) and implant removal/replacement methods used in the treatment of fracture-related infections, and to determine the infection-free fracture healing rates and the factors affecting treatment success.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* internal fixation after fracture
* presence of fistula and/or sinus tract or purulent drainage with dehiscence at the incision site
* at least 2 positive deep tissue cultures or at least 3 positive soft tissue cultures
* early onset of symptoms (6 weeks)
* DAIR or implant removal/replacement due to fracture-related infection
Exclusion Criteria:
* Under 18 years old patients
* prosthetic joint infection
* only conservative treatment applied
* pathological fracture due to primary bone tumor
* simultaneous infection foci in the same extremity
* fracture-related infection not confirmed by international consensus criteria
* poor reduction after internal fixation
* inappropriate or inadequate internal fixation
* radiological images less than 1 year old
* findings starting late (after 6 weeks)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.