Acute Muscular and Vascular Responses to a Single Session of Exercise With BFR in COPD

Inclusion Criteria: * Negative pregnancy test and use of an acceptable contraceptive method throughout the study duration for women of childbearing potential * Established COPD defined as obstructive ventilatory defect (FEV1/FVC \< 0.70 or below the 5th percentile) * Resting lung hyperinflation defined as functional residual capacity \> 2.5 z-scores according to the Global Lung Function Initiative (GLI) * Clinical stability of COPD for at least 3 months, with no recent exacerbation requiring treatment modification * Covered by a national health insurance system * Able and willing to provide written informed consent Non-inclusion Criteria: * Presence of a medical device incompatible with magnetic stimulation * Inability to perform an exercise test on a cycle ergometer * Any usual contraindication to exercise testing, including: * Recent myocardial infarction (3-5 days) * Unstable coronary insufficiency * Severe stenotic valvular disease * Uncontrolled arrhythmia with hemodynamic instability * Recent unexplained syncope * Uncontrolled heart failure * Uncontrolled arterial hypertension (systolic blood pressure ≥200 mmHg and/or diastolic blood pressure ≥110 mmHg at rest) * Acute thromboembolic disease and/or pulmonary edema * Conditions contraindicating the use of blood flow restriction (BFR), including: * Coagulation disorder * Peripheral neuropathy * Uncontrolled hypertension (\>160/100 mmHg) * Peripheral arterial disease * History of venous throm…