The increasing number of adults aged 75 years and older highlights the need for effective, low-cost interventions to preserve cardiovascular health, functional independence, and cognitive performance and to support healthy aging. Beetroot extract (BE), derived from "Beta vulgaris", contains high levels of inorganic nitrate and other bioactive compounds that may positively influence vascular and neuromuscular function. In parallel, multicomponent physical exercise is recognized as an effective strategy to improve physical and cognitive outcomes in older adults. However, evidence on the independent and combined effects of BE supplementation and structured exercise in very old adults remains limited. This randomized controlled trial is designed to evaluate the effects of BE supplementation, alone and in combination with a multicomponent physical exercise program, on blood pressure, functional performance, and cognitive function in adults aged 75 years and older. Participants will be randomly assigned to one of four groups: BE supplementation, multicomponent exercise, combined BE supplementation and exercise, or a control condition, over a predefined intervention period. The exercise program will include strength, balance, mobility, and aerobic components specifically adapted to the abilities and safety requirements of old adults. The primary outcomes of the study will assess changes in cardiovascular health, physical and functional performance, and cognitive function using standardized and validated assessment tools. Secondary outcomes will include additional indicators of physical capacity and health-related quality of life. This trial aims to provide clinically relevant evidence on whether BE supplementation, alone or in combination with multicomponent exercise, represents a practical and scalable intervention to improve cardiovascular, functional, and cognitive health in adults aged 75 years and older.
Age range
75 Years
Sex
ALL
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Blood Pressure
Timeframe: At baseline - 6 weeks - 12 weeks
Heart rate
Timeframe: [Time Frame: Baseline - 6 weeks and 12 weeks]
Stroop Test
Timeframe: At baseline - 6 weeks - 12 weeks
Symbol Digit Modalities Test (SDMT)
Timeframe: At Baseline - 6 weeks - 12 weeks
Trail Making Test - A (TMT-A)
Timeframe: At baseline - 6 weeks - 12 weeks
6 minute walk test (6MWT)
Timeframe: At baseline - 6 weeks - 12 weeks
Short Physical Performance Battery (SPPB)
Timeframe: At baseline - 6 weeks - 12 weeks
Strength
Nicolas Martinez-Velilla, Md-PhD
Timeframe: At baseline - 6 weeks - 12 weeks
Quality of life (QoL)
Timeframe: At baseline - 12 weeks
Medication Use (Polypharmacy and Psychotropic Drugs)
Timeframe: At baseline - 12 weeks
Sleep Health Index (SATED)
Timeframe: At baseline - 12 weeks
Nutritional Status
Timeframe: At baseline
Barthel Index
Timeframe: At baseline
International Physical Activity Questionnaire (IPAQ)
Timeframe: At baseline
Mini-Mental State Examination (MMSE)
Timeframe: At baseline