Efficacy of Clobetasol Vs Intralesional Triamcinolone in Lichen Planus Treatment (NCT07666620) | Clinical Trial Compass
Not Yet RecruitingPhase 4
Efficacy of Clobetasol Vs Intralesional Triamcinolone in Lichen Planus Treatment
Pakistan50 participantsStarted 2026-10-01
Plain-language summary
The purpose of this study is to compare the efficacy and safety of two standard corticosteroid treatments for hypertrophic lichen planus (HLP), a chronic inflammatory skin condition that causes thick, intensely itchy plaques.
Patients participating in the study will be randomly assigned to one of two treatment groups:
* Group A will apply a superpotent topical steroid cream (Clobetasol propionate 0.05%) to their lesions twice daily for 12 weeks.
* Group B will receive intralesional injections of a steroid medication (Triamcinolone acetonide 10 mg/mL) directly into the lesions once every 4 weeks for a total of four sessions over 12 weeks.
The primary objective is to determine which approach achieves a better reduction in plaque thickness and severity using the Lichen Planus Severity Index (LPSI) score at week 12. The study will also track changes in itching severity using a Visual Analog Scale (VAS), changes in overall lesion surface area, and monitor for any local side effects such as skin thinning or pigment changes.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age \>= 18 years, both genders\[cite: 1\]
* Confirmed clinically as hypertrophic lichen planus with Lichen Planus Severity Index (LPSI) score \>= 2 at baseline and Pruritus Visual Analog Scale (VAS) score \>= 4 at baseline\[cite: 1\]
* No use of topical or intralesional treatment of lichen planus within the last 4 weeks\[cite: 1\]
* Able to provide written informed consent in English or Urdu language\[cite: 1\]
Exclusion Criteria:
* Drug-induced lichenoid lesions\[cite: 1\]
* Pregnant or lactating women\[cite: 1\]
* Uncontrolled diabetes mellitus or any other active skin infections\[cite: 1\]
* Necessity of systemic corticosteroids or immunosuppressive drugs as the primary treatment\[cite: 1\]
* Previous history of hypersensitivity or sensitivity to the study medicines (clobetasol propionate or triamcinolone acetonide)\[cite: 1\]
* Refusal to provide informed consent\[cite: 1\]
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.