SCTB41 Plus SCTB39G With or Without Standard Therapy in Advanced Solid Tumors (NCT07665970) | Clinical Trial Compass
Not Yet RecruitingPhase 1/2
SCTB41 Plus SCTB39G With or Without Standard Therapy in Advanced Solid Tumors
112 participantsStarted 2026-06-30
Plain-language summary
This study aims to evaluate the safety, tolerability, PK characteristics, immunogenicity, and preliminary anti-tumor efficacy of SCTB41 in combination with SCTB39G with or without standard therapy in adult patients with advanced malignant solid tumors. This study is an open label, multicentre, dose-escalation and dose-expansion Phase I/II clinical trial.
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Voluntarily sign the informed consent form (ICF);
. Male or female, ≥ 18 years and ≤ 75 years old;
. Survival duration more than 3 months;
. ECOG score ≤ 1 point;
. Histologically or cytologically confirmed diagnosis of advanced malignant solid tumor；
. At least one measurable tumor lesion according to RECIST v1.1;
. Adequate organ and bone marrow function.
Exclusion criteria
. Has participated in another clinical study within 4 weeks prior to the first dose;
. Has previously received other immunotherapies other than PD-(L)1 inhibitors；
. Other malignancies diagnosed within 5 years prior to the enrollment;
. Participants with brainstem, meningeal, spinal metastases, or compression; active central nervous system metastases;
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.