JUgular Gating for Upright Level Adjustment and Targeted Enhancement of Cerebral Perfusion (NCT07665606) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
JUgular Gating for Upright Level Adjustment and Targeted Enhancement of Cerebral Perfusion
France30 participantsStarted 2026-09-01
Plain-language summary
Investigators aim to demonstrate that the evolution of intracranial pressure (ICP) is nonlinear and may be influenced by jugular vein collapse. This collapse is estimated to occur at the angle where the hydrostatic pressure of the blood column matches the central venous pressure, and it can be assessed using ultrasonography. This approach allows for the determination of an individualized tilt angle, optimizing cerebral perfusion pressure without compromising venous drainage.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients ≥ 18 years old
* Hospitalized in the neurocritical care unit or the trauma unit
* Scheduled for nursing care requiring a supine position.
* Arterial catheter allowing continuous measurement of mean arterial pressure.
* Central venous catheter for continuous measurement of central venous pressure.
* External ventricular drain or intracranial pressure sensor for intracranial pressure monitoring.
* Bed with controlled inclination capability.
* Clinically stable condition allowing transient positional changes (as judged by the clinician).
* Not included, or planned to be included in another trial.
Exclusion Criteria:
* Contraindication to trunk mobilization.
* Being a minor or placed under supervision.
* Hemodynamic or respiratory instability.
* Uncontrolled intracranial hypertension, refractory arterial hypertension, or severe dysautonomia.
* Pregnancy or breastfeeding.
* Refusal to participate in the study.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.