This randomized controlled clinical trial aims to evaluate the effect of hyaluronic acid (HA) and particulate bone graft on the peri-implant tissue phenotype in patients receiving dental implants. Healthy adult participants requiring dental implant placement will be randomly allocated into one of three equal groups (12 implants per group): Group 1 will receive dental implants combined with hyaluronic acid gel (Gengigel); Group 2 will receive dental implants combined with both hyaluronic acid and particulate bone graft; and the control group will receive dental implants alone. Clinical and radiographic assessments will be performed using a customized measurement stent to ensure standardized evaluations at baseline, immediately postoperatively, and at 8 and 16 weeks of follow-up. The primary and secondary outcomes include alterations in ridge width, keratinized tissue width/thickness, radiographic soft tissue height, and marginal bone height. The study aims to determine whether the adjunctive use of hyaluronic acid and bone grafts enhances the quality of the peri-implant soft and hard tissue phenotype.
Age range
18 Years – 75 Years
Sex
ALL
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Ridge Width Changes (RW)
Timeframe: Baseline (preoperative), immediate postoperative, 8 weeks, and 16 weeks.
Bone Width (BW)
Timeframe: Baseline (preoperative), and 16 weeks postoperatively
Change in width of keratinized tissue (KTW)
Timeframe: Baseline (preoperative), 8 weeks, and 16 weeks
Keratinized Tissue Thickness (KTT)
Timeframe: Baseline (preoperative), and 16 weeks postoperatively
Radiographic Mucosal Thickness (RT)
Timeframe: Baseline (preoperative), immediate postoperative, 8 weeks, and 16 weeks
Crestal Bone Height (BH)
Timeframe: Immediate postoperative, 8 weeks, and 16 weeks