Pramipexole vs Placebo Treatment in Bipolar Disorder With Anhedonic Depression

Inclusion Criteria: * The participant has given their written consent to participate in the trial. * For WOCBP, adequate contraception should be used (see section 9.6) and a negative pregnancy test is (u-hCG) required. WOCBP: For the purpose of this protocol, a woman is considered of childbearing potential, i.e. fertile, following menarche and until becoming post-menopausal unless permanently sterile. Permanent sterilisation methods include hysterectomy, bilateral salpingectomy and bilateral oophorectomy. A postmenopausal state is defined as no menses for 12 months without an alternative medical cause. * Age ≥18 years ≤80 years. * Diagnosis of bipolar disorder type I or II as verified by ICD-11. * Ongoing depressive state according to ICD-11 (at least 2 weeks, maximum 18 months). * Significant anhedonia, defined as 3 or 4 points on ≥3 items on the SHAPS self-rating scale * Minimum score on the MADRS expert rating scale ≥ 20 * Ongoing treatment with at least one mood stabilising agent (with sufficient antimanic protection as determined by clinical judgment). If treatment with lithium is ongoing, serum levels must be within the reference range of 0.4-0.9. The latest concentration measurement should be within one month before treatment initiation. If treatment is ongoing with a mood stabilising anticonvulsant or an antipsychotic, any dose adjustments made within 4 weeks prior to study start must be reported. Mood-stabilising anticonvulsants and antipsychotics must not be newly …