Comparative Efficacy of Different Dentin Occluding Toothpaste Technologies (NCT07664592) | Clinical Trial Compass
Not Yet RecruitingPhase 3
Comparative Efficacy of Different Dentin Occluding Toothpaste Technologies
132 participantsStarted 2026-06-29
Plain-language summary
The purpose of this clinical study is to evaluate and compare how well three different types of toothpaste technologies work to relieve tooth sensitivity, also known as dentin hypersensitivity. The study asks the question: How effective are toothpastes containing 8% Arginine, 8% Arginine with Zinc Phosphate, or 5% Calcium Sodium Phosphosilicate (CSPS) at providing immediate and short-term relief for people suffering from sensitive teeth?
Who can participate
Age range
18 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Sign an Informed Consent Form;
. Male or female 18 to 70 years of age, inclusive;
. Be in good general health as determined by the study investigators (absence of any condition that, in the opinion of the Principal Investigator, might constitute a risk to the subject while participating in the study. Examples include heart problems, valve/hip replacements, etc);
. Willingness to provide information related to their medical history;
. Available for the two (2) weeks duration of the study;
. Minimum of 16 uncrowned permanent natural teeth (excluding third molars and crowns);
. Must present at least two (2) sensitive teeth which must meet ALL of the following criteria:
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change from Baseline in Dentin Hypersensitivity (1)
Timeframe: Baseline and Immediately post-treatment
2
Title: Change from Baseline in Dentin Hypersensitivity (2)
Timeframe: Baseline and 1 Day
3
Title: Change from Baseline in Dentin Hypersensitivity (3)
Timeframe: Baseline and 3 Days
4
Title: Change from Baseline in Dentin Hypersensitivity (4)
Timeframe: Baseline and 7 Days
5
Title: Change from Baseline in Dentin Hypersensitivity (5)
. Be anterior to the molars and demonstrating dentin exposure due to cervical erosion/abrasion and/or gingival recession;
Exclusion criteria
. Gross oral pathology, chronic disease, and/or history of allergies to any of the test products;
. Use of a desensitizing oral care product and/or recipient of any dental desensitizing treatment within the past month prior to start of the study;
. Advanced periodontal disease and/or treatment for periodontal disease (including surgery) within the past twelve months, dental cleaning it's permitted;
. Sensitive teeth with a mobility greater than one;
. Teeth with extensive/defective restorations (including prosthetic crowns), suspected pulpitis, caries, cracked enamel, or used as abutments for removable partial dentures;
. Current use of anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory drugs, daily use of analgesics within one month prior to the start of the study or scheduled to start such intake during the course of the study; to be defined by the dental examiner; or other drugs that could affect pain sensation;
. Current smokers and subjects with a history of alcohol or drug abuse;
. Participation in any other oral clinical study for the duration of this study;