RecruitingNot Applicable

Cryoneurolysis Versus Radiofrequency in Knee Osteoarthritis

Egypt60 participantsStarted 2026-06-10

Plain-language summary

The project will evaluate the effectiveness of Cryoneurolysis versus radiofrequency procedures in adult patients who are resistant to traditional treatment for knee pain. They are a drug-free pain management procedure.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. adults between the ages of 30 and 70 years with a clinical diagnosis of refractory knee OA who suffered from knee pain.
. Patients who cannot afford intra-articular injections.
. patients who had failed 2 different oral pain medications, and 6 weeks of physical therapy.

Exclusion criteria

. Patients with OA show improvement in pain after physiotherapy.
. patients evaluated by an orthopedic surgeon and deemed to be surgical candidates due to knee pathologies other than OA.
. pregnant patients.
. patients on anticoagulation therapy, who were not permitted to stop anticoagulation.
. patients with previous trauma, neurological or endocrine diseases like diabetes mellitus, and knee tumors; and patients with inflammatory arthritis.
. people who had received an intra-articular knee injection within the last 6 months.
. Patients with tendon tears, bursitis, or calcified tendonitis as proven by imaging.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in visual analogue scale after intervention

Timeframe: immediately after intervention

Trial details

NCT IDNCT07664371

SponsorTanta University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-11

Contact for this trial

Aliaa Mamdouh Abdelaziz Farag, MD

+201069468486 aliaa.mamdouh@med.tanta.edu.eg

View on ClinicalTrials.gov More Knee Osteoarthritis trials