A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in… (NCT07662135) | Clinical Trial Compass
RecruitingPhase 3
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin
United States, Bulgaria, China900 participantsStarted 2026-07-06
Plain-language summary
The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron, compared with placebo in adults with type 2 diabetes mellitus (T2DM) and impaired renal function, who are or will be on a background of sodium-glucose cotransporter 2 inhibitor (SGLT2i) dapagliflozin 10 mg as per guideline directed medical therapy (GDMT) for chronic kidney disease (CKD). Additionally, participants are on other glucose-lowering medication(s).
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. On stable dose of SGLT2i ≥ 7.0 % to ≤ 10.5% (53 to 91.3 mmol/mol)
. SGLT2i-naive ≥ 7.5% to ≤ 10.5% (58 to 91.3 mmol/mol)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this trial specifically requires participants to already be on dapagliflozin, would I need to be taking that medication before I could even be considered for this study, and is dapagliflozin something that makes sense for my current situation?
2This is a Phase III trial, meaning it's in a later stage of testing — does that mean there's more known about elecoglipron's safety profile compared to earlier-phase studies, and what are the main risks still being evaluated?
3Because this trial is focused on people with both Type 2 diabetes and impaired kidney function, how does my current kidney function level factor into whether this study could be appropriate to discuss with my care team?
4The main thing being measured is the change in my HbA1c level — based on where my HbA1c stands right now, is that a meaningful goal for my treatment, or would a different approach address my diabetes management better?
5Since part of this trial involves a placebo group, is there a chance I could go without an active treatment for my diabetes during the study, and how would my care team monitor and protect my health if that happened?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.