Remifentanil vs Esmolol During Intubation for Cerebral Aneurysm Coil Embolization (NCT07660861) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Remifentanil vs Esmolol During Intubation for Cerebral Aneurysm Coil Embolization
Turkey (Türkiye)84 participantsStarted 2026-06-22
Plain-language summary
Endotracheal intubation may cause significant increases in blood pressure, heart rate, and intracranial pressure, particularly in patients undergoing cerebral aneurysm coil embolization. Remifentanil and esmolol are commonly used agents to attenuate these responses during anesthesia induction.
This randomized controlled trial aims to compare the effects of remifentanil and esmolol administered before endotracheal intubation on optic nerve sheath diameter/eyeball transverse diameter ratio (ONSD/ETD), a noninvasive surrogate marker of intracranial pressure, as well as hemodynamic responses in patients undergoing elective cerebral aneurysm coil embolization.
The findings may help identify the most effective strategy for minimizing intubation-related intracranial pressure changes and hemodynamic fluctuations in neurointerventional anesthesia practice.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥18 years
* American Society of Anesthesiologists (ASA) physical status I-III
* Scheduled for elective cerebral aneurysm coil embolization under general anesthesia
* Planned endotracheal intubation
* Ability to provide written informed consent
Exclusion Criteria:
* Emergency procedures
* Hemodynamic instability before induction of anesthesia
* Severe cardiac conduction abnormalities or clinically significant arrhythmias
* Contraindication or allergy to remifentanil or esmolol
* Chronic opioid use or opioid dependence
* Known orbital disease, ocular trauma, or conditions interfering with optic nerve sheath diameter measurements
* Anticipated difficult airway
* Pregnancy
* Refusal to participate in the study
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in ONSD/ETD Ratio at 5 Minutes After Endotracheal Intubation
Timeframe: 5 minutes after endotracheal intubation
Trial details
NCT IDNCT07660861
SponsorFatih Sultan Mehmet Training and Research Hospital