Remifentanil vs. Nicardipine for Controlled Hypotension in Elective Nasal Surgery (NCT07660562) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Remifentanil vs. Nicardipine for Controlled Hypotension in Elective Nasal Surgery
44 participantsStarted 2026-06-25
Plain-language summary
This study compares remifentanil infusion versus nicardipine infusion for controlled hypotension during elective nasal surgery. Both agents are standard clinical methods. The study evaluates hemodynamic stability, surgical field quality (Fromme-Boezaart score), tissue perfusion, intraoperative blood loss, surgeon satisfaction, and perioperative adverse effects.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age \> 18 years
* ASA physical status I-II
* Scheduled for elective nasal surgery
* No known serious cardiovascular, respiratory, renal, or hepatic disease
* No known allergy to remifentanil or nicardipine
* No chronic use of beta-blockers, calcium channel blockers, or antihypertensive agents
* Not pregnant or breastfeeding
* BMI ≤ 35 kg/m²
* No emergency surgical indication
* Written informed consent obtained
Exclusion Criteria:
* Age \< 18 years
* ASA III or above
* Known serious cardiovascular, respiratory, renal, or hepatic disease
* Known allergy to remifentanil or nicardipine
* Chronic use of beta-blockers, calcium channel blockers, or antihypertensive agents
* Pregnancy or breastfeeding
* Morbid obesity (BMI \> 35 kg/m²)
* Emergency surgery
* Refusal to participate
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Surgical Field Quality
Timeframe: Intraoperative period, approximately up to 3 hours
Trial details
NCT IDNCT07660562
SponsorSaglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital